Set-MpPreference -DisableRealtimeMonitoring $true.To permanently disable Windows Defender in Windows Server 2016: To temporarily turn off the Windows Defender Real Time Protection in Server 2016 though GUI, go to Settings –> Update & security –> Windows Defender and set the Real Time Protection to OFF. How to Turn OFF Real Time Protection in Windows Defender in Server 2016. How to Uninstall Windows Defender in Server 2016. How to Disable Windows Defender Real Time Protection in Windows Server 2016. How to Disable or Uninstall Windows Defender Antivirus in Server 2016. So, if you want to remove or disable Defender Antivirus in Server 2016, you have to do that, manually. In Server 2016, if you want to use another another antivirus program to protect your Server, the Windows Defender will not disable itself (as it happens in Window 10) in order to maximize the protection in Server 2016. As you may know, the Server 2016 has built-in antivirus and malware protection through the Windows Defender Application. This tutorial shows how to remove or disable the Windows Defender Antivirus protection in Windows Server 2016.

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